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Endometrial Receptivity Analysis (ERA)

Department of Endometrial Receptivity Analysis (ERA)

The Endometrial Receptivity Array ‘ERA’ is a genetic test that can be used to assess when the lining of the womb is most receptive to the embryo. This test was developed in order to try to improve the likelihood of the embryo implanting in women who have had several failed embryo transfers.

Before

Before undergoing Endometrial Receptivity Analysis (ERA), several tests may be conducted to assess the reproductive health of the individual. Common tests include:

1.Hormonal Assessments: Blood tests to measure hormone levels, including estradiol and progesterone, to evaluate the hormonal milieu related to the menstrual cycle.

2.Ultrasound Imaging: A transvaginal ultrasound may be performed to assess the thickness and appearance of the endometrial lining.

3.Hysteroscopy (if needed): A procedure involving a thin tube with a camera to visualize the inside of the uterus and identify any structural abnormalities.

Types

1.ERA Test: This test involves obtaining an endometrial biopsy to assess the gene expression profile of the endometrium. It helps determine the optimal timing for embryo transfer by evaluating the receptivity of the uterine lining.

Treatment

The ERA test requires an endometrial biopsy which should be carried out 5 days after ovulation of a cycle or after starting Progesterone in a medicated cycle. The biopsy is quick and easy and is done by your gynaecologist. The ERA test analyses the expression levels of 236 genes linked to the status of endometrial receptivity, using RNA sequencing taken from the endometrial tissue.

Endometrial Receptivity Analysis (ERA) Overview

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